mitochondrialdysfunction相关论文
Prion disease represents a group of fatal neurogenerative diseases in humans and animals that are associated with energy......
Acanthopanax senticosus Protects Structure and Function of Mesencephalic Mitochondria in A Mouse Mod
Objective:To investigate the neuro-protective effects of Acanthopanax senticosus Harms (EAS)on mesencephalic mitochondri......
Advanced Glycation End Products promote human intervertebral disc degeneration via NLRP3inflammasome
Objective:Intervertebral disc(IVD)degeneration is widely recognized as a contributor to low back pain,neurological dysfu......
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Spinocerebellar ataxia type 3/Machado-Joseph disease(SCA3/MJD)is the most common subtypes of spinocerebellar ataxias in ......
Respiratory chain complexes are organized into large supercomplexes,among which supercomplex Ⅰ+Ⅲ2+IVn,is the only supe......
Adriamycin induced DNA damage,p53-regulated mitochondrial dysfunction and caspase-dependent apoptosi
Purpose To investigate the mechanisms of adriamycin(ADR)for proliferative vitreoretinopathy(PVR)treatment by using human......
Neuroprotective effects of plant extracts against the neurotoxicity induced by rotenone, a mitochond
Aim: Rotenone, an inhibitor of mitochondnal complex Ⅰ, has been widely regarded as a neurotoxin because it induces a Pa......
Current pharmacological therapies used in clinical practice for individuals with cardiac, hepatic, renal or pulmonary fi......
BAG5 interacts with the Parkinson-associated protein PINK1 to protect against oxidative mitochondria
Mutations in PTEN-induced kinase 1 (PINK1) gene cause PARK6 familial Parkinsonism, and loss the stability of PINK1 may a......
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Study on the transcription of PD-related genes and expression of DNA methyltransferases induced by 1
Parkinsons disease (PD) is a common neurodegenerative disorder,and it is characterized by a selective and progressive lo......
B19,a novel monocarbonyl analogue of curcumin,inducesros-mediated apoptosis via targeting TrxR1 in g
The thioredoxin reductase(TrxR)1 is often overexpressed in numerous cancer cells.Targeting TrxR1 leads to a reduction in......
Mitochondria play critical role in neuronal function and survival and mitochondrial abnormalities and dysfunction have b......
Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during i
Silent information regulator 1 (SIRT1), a type of histone deacetylase, is a highly effective therapeutic target for prot......
Involvement of Mitochondrial Uncoupling Protein 4 in Chronic Pain via Alleviating Mitochondrial Dysf
Mitochondria are the most important organelles in neurons with essential functions, yet very little research has address......
Implication of Elevated Endogenous Nitric Oxide Synthase Inhibitor in the Cardiac Dysfunction of Typ
Objective: Diabetes mellitus is one of the most common illnesses seriously harmful to human health.The major complicatio......
Mitochondrial dysfunction promotes breast cancer cell migration and invasion through HIF1α accumulat
Although mitochondrial dysfunction has been observed in various types of human cancer cells, the molecular mechanism und......
FoxO1 mediates mitochondria degradation in the heart of rats modeling type 2 diabetes mellitus: Regu
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Background: As an important constituent of atmospheric particulate matter(PM),ultrafine black carbon(uBC)could potential......
Design,Synthesis,and Anticancer Effect Studies of Iridium(Ⅲ)Polypyridyl Complexes against HeLa Cells
An iridium(Ⅲ)complex([Ir(PTTP)2(ppy)](PF6)(Ir-1)were synthesized and characterized.The cytotoxicity of Ir-1 against can......
The jatrorrhizine was the major bioactive alkaloids isolated from Tinospora capillipes Gagnep.[1,2] It was important com......
A novel organoplatinum(Ⅱ)complex,[PtⅡ(QC1)(H-QC1)Cl](Pt1)bearing 3-(2′-quinolyl)-6,8-dichloro-coumarin(H-QC1)have bee......
MITOCHONDRIAL FUNCTION AND TISSUE VIABILITY IN VIVO: FROM ANIMAL EXPERIMENTS TO CLINICAL APPLICATION
The involvement of mitochondrial dysfunction in many pathophysiological conditions and human diseases is well documented......
Mitochondrial transfer from bone-marrow-derived mesenchymal stromal cells to chondrocytes protects a
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Objective:Capsaicin (CPS) is a major component of the red pepper,and its anti-tumor property has been confirmed.However,......
Cardiac glycosides are natural compounds which have long been used to treat cardiac congestion and arrhythmia by sel......
Methods Cell viability was assessed by MTT assay.AO/EB,Hoechst 33258 staining assay,cell colony formation and migrat......
Induction of Cardiac Dysfunction by Exogenous Inhibitor of Nitric Oxide Synthase via Affecting Mitoc
Aim: Diabetic patients are easily suffered from cardiovascular diseases, especially diabetic cardiomyopathy (DCM) which ......
Adenylate cyclase activator forskolin alleviates intracerebroventricular propionic acid-induced mito
Neuronal mitochondrial dysfunction increases inflammatory mediators and leads to free radical genera-tion and anti-oxida......
目的 观察肿瘤坏死因子(TNF-α)诱导的离体血管内皮细胞损伤后线粒体功能、过氧化物酶体增殖物活化受体γ共激活因子-1α(PGC-1α)......
Ezetimibe was reported to pharmacologically defend against oxidative stress.This study was designed to investigate wheth......
miR-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute
Supplemental oxygen is commonly used to treat severe respiratory failure,while prolonged expo-sure to hyperoxia can indu......
Huntington disease (HD) is a chronic autosomal-dominant neurodegenerative disease. The gene coding Huntingtin has been i......
